Delineation of a novel dendritic-like subset in human spleen
نویسندگان
چکیده
منابع مشابه
Delineation of precursors in murine spleen that develop in contact with splenic endothelium to give novel dendritic-like cells.
Hematopoietic cell lineages are best described in terms of distinct progenitors with limited differentiative capacity. To distinguish cell lineages, it is necessary to define progenitors and induce their differentiation in vitro. We previously reported in vitro development of immature dendritic-like cells (DCs) in long-term cultures (LTCs) of murine spleen, and in cocultures of spleen or bone m...
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A novel dendritic-like cell subset termed L-DC was recently identified in murine spleen based on marker expression of a homogeneous cell population derived from long-term culture of neonatal spleen. The function of L-DC is distinct from other splenic dendritic and myeloid cell subsets because of their high endocytic capacity and their ability to cross-present antigen to CD8(+) T cells. This pap...
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Hematopoietic cell lineages are best described in terms of distinct progenitors with limited differentiative capacity. To distinguish cell lineages, it is necessary to define progenitors and induce their differentiation in vitro. We previously reported in vitro development of immature dendritic-like cells (DCs) in long-term cultures (LTCs) of murine spleen, and in cocultures of spleen or bone m...
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ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2015
ISSN: 1672-7681,2042-0226
DOI: 10.1038/cmi.2015.16